Bestimmung von Insulinresistenz und Insulinsensitivität bei Kindern und Jugendlichen
Identifieur interne : 009910 ( Main/Exploration ); précédent : 009909; suivant : 009911Bestimmung von Insulinresistenz und Insulinsensitivität bei Kindern und Jugendlichen
Auteurs : E. Heinze [Allemagne] ; T. Horn [Allemagne] ; M. Wabitsch [Allemagne] ; S. Wudy [Allemagne] ; W. Sorgo [Allemagne] ; J. Homoki [Allemagne]Source :
- Monatsschrift für Kinderheilkunde [ 0026-9298 ] ; 2002.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Enfant.
English descriptors
- KwdEn :
Abstract
Background. The hyperinsulinimic euglycemic clamp is the gold standard to determine insulin action. In adults simpler methods to define insulin resistance (HOMA) and -sensitivity (ISI) are available. In children/adolescents HOMA and ISI were evaluated and correlated with BMI and blood pressure. Patients. 59 children/adolescents of comparable age were divided into a control group: 23 patients, the Ullrich-Turner group: 14 girls,the obese group: 22 patients. Results. HOMA increased from controls to obesity, while ISI decreased.The association between HOMA and ISI was hyperbolic with R=0.88.The correlation between HOMA and BMI and blood presure was positive and negative for ISI. In one patient the coefficient of variation for HOMA was 30% and 26% for ISI. Conclusion. It appears that in children and adolescents HOMA and ISI may be suitable methods to determine insulin action.
Affiliations:
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Heinze</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Kinderklinik, Universität Ulm</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><settlement type="city">Ulm</settlement><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Horn, T" sort="Horn, T" uniqKey="Horn T" first="T." last="Horn">T. Horn</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Kinderklinik, Universität Ulm</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><settlement type="city">Ulm</settlement><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Wabitsch, M" sort="Wabitsch, M" uniqKey="Wabitsch M" first="M." last="Wabitsch">M. Wabitsch</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Kinderklinik, Universität Ulm</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><settlement type="city">Ulm</settlement><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Wudy, S" sort="Wudy, S" uniqKey="Wudy S" first="S." last="Wudy">S. Wudy</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Kinderklinik, Universität Giessen</s1><s3>DEU</s3><sZ>4 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Universität Giessen</wicri:noRegion><wicri:noRegion>Kinderklinik, Universität Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Sorgo, W" sort="Sorgo, W" uniqKey="Sorgo W" first="W." last="Sorgo">W. Sorgo</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Kinderklinik, Universität Ulm</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><settlement type="city">Ulm</settlement><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Homoki, J" sort="Homoki, J" uniqKey="Homoki J" first="J." last="Homoki">J. Homoki</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Kinderklinik, Universität Ulm</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><settlement type="city">Ulm</settlement><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author></analytic><series><title level="j" type="main">Monatsschrift für Kinderheilkunde</title><title level="j" type="abbreviated">Mon.schr. Kinderheilkd.</title><idno type="ISSN">0026-9298</idno><imprint><date when="2002">2002</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Monatsschrift für Kinderheilkunde</title><title level="j" type="abbreviated">Mon.schr. Kinderheilkd.</title><idno type="ISSN">0026-9298</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Arterial pressure</term><term>Body mass index</term><term>Bonnevie Ulrich syndrome</term><term>Child</term><term>Evaluation</term><term>Gonad</term><term>Insulin</term><term>Method</term><term>Nutritional status</term><term>Obesity</term><term>Sensitivity</term><term>Statistical analysis</term><term>Target tissue resistance</term><term>Turner syndrome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Insuline</term><term>Résistance tissu cible</term><term>Sensibilité</term><term>Indice masse corporelle</term><term>Pression artérielle</term><term>Turner syndrome</term><term>Bonnevie Ulrich syndrome</term><term>Obésité</term><term>Méthode</term><term>Evaluation</term><term>Analyse statistique</term><term>Enfant</term><term>Adolescent</term><term>Gonade</term><term>Etat nutritionnel</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enfant</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background. The hyperinsulinimic euglycemic clamp is the gold standard to determine insulin action. In adults simpler methods to define insulin resistance (HOMA) and -sensitivity (ISI) are available. In children/adolescents HOMA and ISI were evaluated and correlated with BMI and blood pressure. Patients. 59 children/adolescents of comparable age were divided into a control group: 23 patients, the Ullrich-Turner group: 14 girls,the obese group: 22 patients. Results. HOMA increased from controls to obesity, while ISI decreased.The association between HOMA and ISI was hyperbolic with R=0.88.The correlation between HOMA and BMI and blood presure was positive and negative for ISI. In one patient the coefficient of variation for HOMA was 30% and 26% for ISI. Conclusion. It appears that in children and adolescents HOMA and ISI may be suitable methods to determine insulin action.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Tübingen</li></region><settlement><li>Ulm</li></settlement><orgName><li>Université d'Ulm</li></orgName></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Heinze, E" sort="Heinze, E" uniqKey="Heinze E" first="E." last="Heinze">E. Heinze</name></region><name sortKey="Homoki, J" sort="Homoki, J" uniqKey="Homoki J" first="J." last="Homoki">J. Homoki</name><name sortKey="Horn, T" sort="Horn, T" uniqKey="Horn T" first="T." last="Horn">T. Horn</name><name sortKey="Sorgo, W" sort="Sorgo, W" uniqKey="Sorgo W" first="W." last="Sorgo">W. Sorgo</name><name sortKey="Wabitsch, M" sort="Wabitsch, M" uniqKey="Wabitsch M" first="M." last="Wabitsch">M. Wabitsch</name><name sortKey="Wudy, S" sort="Wudy, S" uniqKey="Wudy S" first="S." last="Wudy">S. Wudy</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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